RAF Typhoon jets have conducted a mission with French aircraft in a coordinated attack targeting an hidden munitions depot in Syrian territory operated by the IS group, according to the UK's MoD.
The location, located using surveillance, was thought to be housing weapons and explosive materials, the statement said, and was located in hills just above the ancient city of Palmyra in central Syria.
"Our fighter planes utilized laser-guided Paveway IV weapons to hit a number of approach shafts down to the site... early reports indicate the strike was effective," officials stated.
There was no indication of any harm to civilians in the strike on Saturday evening and each participating jet returned safely, the ministry further stated.
The British jets were assisted by a Voyager refuelling tanker.
IS - referred to as ISIS - established militant control over large swathes of Syria and Iraq prior to its 2019 collapse.
"This strike shows the UK's leading role, and commitment to operate in unison with our partners, to eradicate any revival of IS and their violent and radical beliefs in the Middle East," the British Defence Secretary the minister said.
RAF aircraft have performed surveillance missions over Syria to "forestall any efforts to regroup" of Islamic State following its military defeat at the climactic battle in Baghuz in the year 2019, the MoD reported.
"I want to thank all the members of British forces who took part in this strike for their professionalism and their bravery," he added. "They were among numerous UK service members on duty over Christmas and New Year. This mission, to take out dangerous terrorists who threaten our security, highlights how our armed forces are prepared to act, throughout the year, protecting the UK within its borders and powerful internationally."
Last December, the United States armed forces conducted what it described as a "major assault" against Islamic State objectives in the country, after an assault claimed the lives of two US servicemembers and a local interpreter in Palmyra.
The U.N. says IS still has between 5,000 and 7,000 combatants in Iraq and Syria.